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Sample Newsletter:

Healthy Hepper.com Bi-Monthly Liver Newsletter
November 12, 2009

1. Amino Acids and Hepatitis C
2. Conventional Med Recap from AASLD meeting
3. Multivitamins, Your Liver and Hepatitis C
1. AMINO ACID THERAPY FOR HEPATITIS C
How are amino acids important to those with Hep C?
http://www.healthyhepper.com/aminoacids.htm

2. Conventional Med Recap from AASLD meeting:
Dr. Zeuzem, a key opinion leader in Hep C, offers his thoughts on the hits and misses coming from last week's big annual meeting of the American Association for the Study of Liver Disease.

Data from Vertex's telaprevir was the most important and discussed during the meeting. The high cure rates seen in the so-called C208 study of treatment-experienced patients were probably as high as the field will ever see with a protease inhibitor. Zeuzem also called the data on twice-daily dosing of telaprevir "convincing," but he's still cautious and would like to see additional, confirmatory data from a larger study.

The Hep C field is moving quickly to test treatment with two direct anti-virals against the Hep C virus, and hopefully eliminate the need for long-acting interferon and ribavirin -- the current standard of care for the disease.

Zeuzem was impressed with the two-week antiviral activity shown in the so-called INFORM-1 study in both treatment-naïve and treatment-experienced patients. This study treats patients with a combination of InterMune's(ITMN Quote) RG7227 and Pharmasset's(VRUS Quote) RG7128. (The study is being co-sponsored by Roche, which co-owns development rights to both drugs.)

Side effects of earlier-stage Hep C drug continue to raise some concerns, including elevated levels of jaundice and bilirubin in patients treated with Boehringer Ingelheim's BI-'335. Zeuzem said more analysis was needed before the side-effect profile of the drug was clear.

Zeuzem said the jury was also still out on Schering-Plough's(SGP Quote) second-generation protease inhibitor narlaprevir, which uses a common HIV drug known as ritonavir to boost blood levels.

Zalbin, a twice-monthly interferon from Human Genome Sciences(HGSI Quote) and Novartis(NVS Quote), might appeal to some patients who care most about reducing the number of injections required. He was less enthusiastic about another long-acting interferon from Zymogenetics(ZGEN Quote) and Bristol-Myers Squibb, mainly because the drug is so early in development that it may become irrelevant if treatment with interferons and ribavirin are shelved due to the success of direct anti-viral drugHe also noted that other companies, including Vertex and Bristol-Myers Squibb(BMY Quote), plan to begin their own two-drug direct anti-viral combination studies next year.
http://www.thestreet.com/story/10624093/1/doc-offers-top-hep-c-drug-picks-biobuzz.html?cm_ven=GOOGLEFI

3. Multivitamins, Your Liver and Hepatitis C
Since vitamins are essential to life and good health, it stands to reason that a well-rounded multivitamin supplement would be helpful to anyone, especially someone with a chronic disease such as Hepatitis C. Learn more about benefits and things to be aware of when selecting yours.
http://www.healthyhepper.com/vitamins.htm

Wishing you health,
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